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Developmental Biology

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JoVE Journal Developmental Biology

从外周单核细胞生成诱导神经干细胞,分化至多巴胺能神经元前体,用于移植研究

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从外周单核细胞生成诱导神经干细胞,分化至多巴胺能神经元前体,用于移植研究

Article DOI: 10.3791/59690-v • 12:13 min • July 11th, 2019

July 11th, 2019 •

Wei Zheng^1,2, Zhiguo Chen^1,2

¹Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, ²Center of Neural Injury and Repair, Beijing Institute for Brain Disorders

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该协议提出了外周血单核细胞的重新编程,以诱导神经干细胞由仙台病毒感染,将iNSCs分化为多巴胺能神经元,将DA前体移植到单方面病变帕金森病小鼠模型,并评价iNSC衍生DA前体用于PD治疗的安全性和有效性。

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发育生物学问题 149 神经科学诱导神经干细胞帕金森病重新编程分化移植外周血单核细胞仙台病毒 6-OHDA 多巴胺能神经元

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