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Sintesi e Bioconjugation di tiolo-reattive reagenti per la creazione del sito-selettivamente per volta efattori

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Chemie

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JoVE Journal Chemie

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

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Sintesi e Bioconjugation di tiolo-reattive reagenti per la creazione del sito-selettivamente per volta efattori

9,036 Views

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08:47 min

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March 06, 2019

DOI:

10.3791/59063-v

DOI:

10.3791/59063-v

•

08:47 min

March 06, 2019

•

6 Views

Maria Davydova, Guillaume Dewaele Le Roi², Pierre Adumeau, Brian M. Zeglis^2,3,4

¹Department of Chemistry,Hunter College of the City University of New York, ²Ph.D. Program in Chemistry,Graduate Center of the City University of New York, ³Department of Radiology,Memorial Sloan Kettering Cancer Center, ⁴Department of Radiology,Weill Cornell Medical College

Tags

Thiol-reactive Reagents Site-specific Bioconjugation Immunoconjugates PODS Maleimide-thiol-based Bioconjugation Aminophenyl Oxadiazole Thiol Diisopropylethylamine Iodomethane Boc-protected Carboxylic Acid Dichloromethane EDCI Aniline Hydrochloric Acid Sodium Carbonate Magnesium Sulfate Ethyl Acetate Cyclohexane Carbamate M-chloroperbenzoic Acid

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