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Journal / Neuroscience / 一种新的脑外伤体损伤模型
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Neuroscience

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JoVE Journal Neuroscience
一种新的脑外伤体损伤模型
 
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一种新的脑外伤体损伤模型

Article DOI: 10.3791/58400-v • 08:59 min • December 21st, 2018
December 21st, 2018 •
1,2, 1, 2,3, 1, 4,5, 6, 1,2
1Anaesthetics, Pain Medicine and Intensive Care Section, Department of Surgery and Cancer, Imperial College London, 2Royal British Legion Centre for Blast Injury Studies, Department of Bioengineering, Imperial College London, 3Department of Bioengineering, Imperial College London, 4Department of Life Sciences, Imperial College London, 5Department of Anaesthetics, Royal Berkshire Hospital NHS Foundation Trust, 6Royal Centre for Defence Medicine, Medical Directorate Joint Force Command

Kapitel

Summary
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本文介绍了一种新的原发性爆炸创伤性脑损伤模型。压缩空气驱动的激波管被用来暴露在体外小鼠海马切片培养器的单个冲击波。这是一个简单而快速的协议, 产生可重复的脑组织损伤, 具有较高的吞吐量。

Tags

神经科学 第142期 爆裂创伤性脑损伤、原发性爆炸损伤、爆炸性神经外伤、休克管、 体外模型、tbi、器官型海马切片培养
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