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Neuroscience

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JoVE Journal Neuroscience
Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
 

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Article DOI: 10.3791/57349-v • 07:33 min • June 29th, 2018
June 29th, 2018 •
1,2, 2,3, 1,2
1Systems Neurophysiology Research Group, Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, 2Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/ NeuroCure Cluster of Excellence, 3Neuronal Circuits and Behavior Research Group, Max Planck Institute for Metabolism Research

Kapitel

Summary
Automatic Translation

We describe the use of optogenetics and electrophysiological recordings for selective manipulations of hippocampal theta oscillations (5-10 Hz) in behaving mice. The efficacy of the rhythm entrainment is monitored using local field potential. A combination of opto- and pharmacogenetic inhibition addresses the efferent readout of hippocampal synchronization.

Tags

Hippocampal Theta Oscillations Neurophysiology Causal Role Special Navigation Associated Behaviors Real-time Control Frequency Regularity Behaving Mice Dr. Franziska Bender Grad Student Stereotaxic Frame Injection Needle Virus Paraffin Film Nanoliters Per Minute Craniotomy Optic Fiber
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