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Biochemistry

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JoVE Journal Biochemistry
Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups
 

Hydrolysis of a Ni-Schiff-Base Complex Using Conditions Suitable for Retention of Acid-labile Protecting Groups

Article DOI: 10.3791/55677-v • 06:44 min • April 6th, 2017
April 6th, 2017 •
1, 1, 1
1Department of Chemistry, Slippery Rock University

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Summary
Automatic Translation

Here, we present an efficient hydrolysis and subsequent Fmoc protection of an amino acid isolated from a Ni-Schiff-base complex. Hydrolysis conditions presented here are suitable for use when retention of acid-labile side-chain protecting groups is required. This technique may be adaptable to a variety of unnatural amino acid substrates.

Tags

Hydrolysis Ni-Schiff-Base Complex Acid-labile Protecting Groups Unnatural Amino Acids Fmoc Protection Organic Chemistry Isolation Solubility Nickel Complex DMF Solvent Water Miscible Inorganic Professor Metal Chelating Agents Round Bottom Flask EDTA Solution PH 4.5 Magnetic Stir Bar Stir Plate Separatory Funnel DCM Solvent
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