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质谱法和基于发光的-途径表征阶段我代谢能力的<em>体外</em>细胞培养
JoVE Journal
Biochemie
This content is Free Access.
JoVE Journal Biochemie
Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
DOI:

10:44 min

March 28, 2017

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Kapitel

  • 00:05Titel
  • 00:48Cell Culture
  • 02:49CYP Activity Quantification in Cell Cultures: Metabolic Probes, Inducers, and Inhibitors
  • 04:30CYP Activity Quantification in Cell Cultures: Medium Treatment
  • 05:40CYP Activity Quantification in Cell Cultures: Mass Spectrometry (MS)-based Quantification
  • 06:49CYP Activity Quantification in Cell Cultures: Probes Using Luminescence-based Methods
  • 08:10Results: Quantification of Metabolites Produced by tha Activity of CYP Enzymes Following Cell Incubation with CYP Inducers, Substrates, and Inhibitors
  • 09:35Conclusion

Summary

Automatische Übersetzung

体外系统的代谢能力是药物和毒物的生物转化和处置的一个关键要求。在这个协议中,我们描述的参考代谢探针的应用,以评估相我在细胞培养物代谢。

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