Journal
/
Medizin
/
만성 아밀로이드 - 베타 올리고머 주입의 동물 모델에서 신경 퇴행은 삼투 펌프와 항체 치료 인 퓨즈에 의해 상쇄되어
JoVE Journal
Medizin
This content is Free Access.
JoVE Journal Medizin
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
Please note that all translations are automatically generated. Click here for the English version.

만성 아밀로이드 - 베타 올리고머 주입의 동물 모델에서 신경 퇴행은 삼투 펌프와 항체 치료 인 퓨즈에 의해 상쇄되어

9,041 Views

•

10:19 min

•

August 14, 2016

DOI:

10.3791/54215-v

DOI:
10.3791/54215-v

•

10:19 min
August 14, 2016

•

8 Views
, , ,
1Department of Pharmacology,Université de Montréal, 2Department of Neuroscience,Université de Montréal, 3Hôpital du Sacré-coeur de Montréal Research Center,Université de Montréal

Summary

Automatically generated

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

Explore More Videos

Amyloid-beta OligomerNeurodegenerationAlzheimer’s DiseaseAnimal ModelAntibody TreatmentOsmotic PumpsCannula ImplantationStereotaxic FrameNeurotoxicityImmunotherapy

Read Article

Cite this Article

Sajadi, A., Provost, C., Pham, B., Brouillette, J. Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps. J. Vis. Exp. (114), e54215, doi:10.3791/54215 (2016).

Download .ris file

Copy

Share Video

.

Copy