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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
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Kapitel
- 00:05Titel
- 00:56Ethanol and Metronidazole Treatment and Liver Regeneration in Larval Zebrafish
- 02:42Chemical Screens in EtOH/MTZ-treated Larval Zebrafish
- 04:10Ethanol and Metronidazole Treatment, and Liver Regeneration in Adult Zebrafish
- 05:24Adult Zebrafish Liver Fixation, Immunostaining, and Confocal Imaging
- 07:30Results: Hepatocyte Regeneration in Ethanol-treated Zebrafish Liver
- 09:25Conclusion
Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.
