Zum Anzeigen dieser Inhalte ist ein JoVE-Abonnement erforderlich. Melden Sie sich an oder starten Sie Ihre kostenlose Testversion.
Desenvolvimento de um Backbone cíclica Biblioteca de Peptídeos como potencial antiparasitário Therapeutics Usando Microondas Irradiação
11,647 Views
•
08:48 min
•
January 26, 2016
DOI:
Summary
Automatically generated
A simple and general method for the synthesis of cyclic peptides using microwave irradiation is outlined. This procedure enables the synthesis of backbone cyclic peptides with a collection of different conformations while retaining the side chains and the pharmacophoric moieties., and therefore, allows to screen for the bioactive conformation.
Explore More Videos
Backbone Cyclic Peptide LibraryAntiparasitic TherapeuticsMicrowave IrradiationProtein-protein InteractionsAmino AcidActivatorActivator BasePolypropylene CartridgeCoupling ReactionNN-dimethylformamidePiperidine1-hydroxybenzotriazoleDichloromethane1-methyl-2-pyrrolidinoneAnhydride4-DimethylaminopyridineNN-diisopropylethylamineTrifluoroacetic AcidTriisopropylsilane
Read Article
Cite this Article
Qvit, N., Kornfeld, O. S. Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation. J. Vis. Exp. (107), e53589, doi:10.3791/53589 (2016).
Copy