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Un modèle de tissu 3D Poumon humain pour les études fonctionnelles sur<em> Mycobacterium tuberculosis</em> Infection
JoVE Journal
Immunologie und Infektion
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JoVE Journal Immunologie und Infektion
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
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Un modèle de tissu 3D Poumon humain pour les études fonctionnelles sur<em> Mycobacterium tuberculosis</em> Infection

18,478 Views

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10:10 min

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October 05, 2015

DOI:

10.3791/53084-v

DOI:
10.3791/53084-v

•

10:10 min
October 05, 2015

•

4 Views
, , , ,
1Department of Clinical and Experimental Medicine,Linköping University, 2Department of Medicine,Karolinska Institute

Summary

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Human tuberculosis infection is a complex process, which is difficult to model in vitro. Here we describe a novel 3D human lung tissue model that recapitulates the dynamics that occur during infection, including the migration of immune cells and early granuloma formation in a physiological environment.

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Braian, C., Svensson, M., Brighenti, S., Lerm, M., Parasa, V. R. A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection. J. Vis. Exp. (104), e53084, doi:10.3791/53084 (2015).

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