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Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier
JoVE Journal
Medizin
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JoVE Journal Medizin
Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier

Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier

14,642 Views

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07:19 min

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October 26, 2013

DOI:

10.3791/50928-v

DOI:
10.3791/50928-v

•

07:19 min
October 26, 2013

•

4 Views
, ,
1Klinik und Poliklinik für Anästhesiologie,Zentrum für operative Medizin der Universität Würzburg, 2Department of Medicinal Chemistry, Faculty of Life Sciences,University of Vienna

Summary

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In vitro traumatic brain injury models are being developed to reproduce in vivo brain deformation. Stretch-induced injury has been employed for astrocytes, neurons, glial cells, aortic, and brain endothelial cells. However, our system uses a blood brain barrier (BBB) model that possesses properties constituting a legitimate model of the BBB to establish an in vitro TBI model.

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Traumatic Brain InjuryTBIIn Vitro ModelBrain Microvascular Endothelial CellsCENDBlood-brain BarrierBBBStretch InjuryPressure ApplicationCell PhysiologyIn Vivo TechniquesCell CultureExperimental Setup

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Cite this Article

Salvador, E., Neuhaus, W., Foerster, C. Stretch in Brain Microvascular Endothelial Cells (cEND) as an In Vitro Traumatic Brain Injury Model of the Blood Brain Barrier. J. Vis. Exp. (80), e50928, doi:10.3791/50928 (2013).

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