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Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland
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Biologie
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JoVE Journal Biologie
Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland

Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland

34,130 Views

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06:39 min

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October 04, 2013

DOI:

10.3791/50692-v

DOI:
10.3791/50692-v

•

06:39 min
October 04, 2013

•

35 Views
, ,
1Vascular Biology Program, Department of Surgery,Boston Children’s Hospital and Harvard Medical School, 2Wyss Institute for Biologically Inspired Engineering,Harvard University, 3Harvard School of Engineering and Applied Sciences

Summary

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A protocol for the non-invasive intraductal delivery of aqueous reagents to the mouse mammary gland is described. The method takes advantage of localized injection into the nipples of mammary glands targeting mammary ducts specifically. This technique is adaptable for a variety of compounds including siRNA, chemotherapeutic agents and small molecules.

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Cite this Article

Krause, S., Brock, A., Ingber, D. E. Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland. J. Vis. Exp. (80), e50692, doi:10.3791/50692 (2013).

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