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Controlled Cervical Laceration Injury in Mice
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May 09, 2013
DOI:
1Norton Neuroscience Institute,Norton Healthcare, 2Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman and Campbell Brain and Spine, Medical Neuroscience Graduate Program, and Department of Anatomy and Cell Biology,Indiana University School of Medicine
Summary
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A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.
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Zhang, Y. P., Walker, M. J., Shields, L. B. E., Wang, X., Walker, C. L., Xu, X., Shields, C. B. Controlled Cervical Laceration Injury in Mice. J. Vis. Exp. (75), e50030, doi:10.3791/50030 (2013).
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