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Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
JoVE Journal
Medizin
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JoVE Journal Medizin
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

DOI:

10:01 min

July 10, 2012

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Kapitel

  • 00:05Titel
  • 01:15Donor Procedure
  • 03:57Graft Preparation
  • 05:30Recipient Procedure
  • 08:27Ergebnisse
  • 09:32Conclusion

Summary

Automatische Übersetzung

Obliterative bronchiolitis is the key impediment to the long-term survival of lung transplant recipients and the lack of a robust preclinical model precludes examining obliterative bronchiolitis immunopathogenesis. Unlike other solid organ transplants, vascularized mouse lung transplantation has only recently been developed. Here we show our independently developed obliterative bronchiolitis model after murine orthotopic single-lung transplantation.

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