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Journal / Biology / Avidity-based Extracellular Interaction Screening …
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Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
 

Avidity-based Extracellular Interaction Screening (AVEXIS) for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions

Article DOI: 10.3791/3881-v • 12:30 min • March 5th, 2012
March 5th, 2012 •
1, 1
1Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute

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Summary
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AVEXIS is a high throughput protein interaction assay developed to systematically screen for novel extracellular receptor-ligand pairs involved in cellular recognition processes. It is specifically designed to detect transient protein interactions that are difficult to identify using other high throughput approaches.

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Avidity-based Extracellular Interaction Screening AVEXIS Low-affinity Interactions Extracellular Receptor-ligand Interactions Intercellular Communication Multicellular Organisms Protein-protein Interactions Binding Partner Membrane-embedded Proteins Posttranslational Modifications Interaction Affinities High Throughput Methods AVEXIS Assay Weak Protein Interactions False Positive Rate High Throughput Format Recombinant Protein Libraries
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