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Procedure for Lung Engineering
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Biotechnik
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JoVE Journal Biotechnik
Procedure for Lung Engineering

Procedure for Lung Engineering

46,248 Views

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12:50 min

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March 08, 2011

DOI:

10.3791/2651-v

DOI:
10.3791/2651-v

•

12:50 min
March 08, 2011

•

7 Views
, ,
1Department of Biomedical Engineering,Yale University, 2Department of Biomedical Engineering, School of Medicine,Duke University, 3Department of Anesthesia,Yale University

Summary

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We have developed a decellularized lung extracellular matrix and novel biomimetic bioreactor that can be used to generate functional lung tissue. By seeding cells into the matrix and culturing in the bioreactor, we generate tissue that demonstrates effective gas exchange when transplanted in vivo for short periods of time.

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Cite this Article

Calle, E. A., Petersen, T. H., Niklason, L. E. Procedure for Lung Engineering. J. Vis. Exp. (49), e2651, doi:10.3791/2651 (2011).

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