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突触改变老化过程中淀粉样蛋白病理研究从大鼠和转基因小鼠海马急性片的制备

JoVE Journal
Neurowissenschaften

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JoVE Journal Neurowissenschaften

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

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突触改变老化过程中淀粉样蛋白病理研究从大鼠和转基因小鼠海马急性片的制备

DOI:

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14:57 min

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March 23, 2011

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Diana M. Mathis, Jennifer L. Furman, Christopher M. Norris³

¹Graduate Center for Gerontology,University of Kentucky College of Public Health, ²Department of Molecular and Biomedical Pharmacology,University of Kentucky College of Medicine, ³Sanders-Brown Center on Aging,University of Kentucky College of Medicine

Kapitel

00:05Titel
01:52Brain Removal and Hippocampal Dissection in Aged Rats
06:41Brain Sectioning Using A Vibrating Microtome
08:12Elicit and Record CA3-CA1 Synaptic Responses
11:32Representative Results
14:31Conclusion

Summary

Automatische Übersetzung

本文概述了程序，准备从老鼠和转基因小鼠海马突触改变与大脑衰老和与年龄有关的神经退行性疾病如阿尔茨海默氏症，相关的研究。

Tags

Acute Hippocampal Slices Rats Transgenic Mice Synaptic Alterations Aging Amyloid Pathology Synaptic Function Plasticity Electrophysiological Techniques Cognitive Impairments Synaptic Plasticity Mechanisms Long-term Potentiation Long-term Depression Nootropic Compounds Brain Aging Alzheimer’s Disease (AD)Aged Rats AD Model Mice

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