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Predicting Amino Acid Preferences of Protein-Protein Binding Interfaces

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Computational Alanine Scanning Mutagenesis of Protein-Peptide Interface

JoVE Journal
Biochemie

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JoVE Journal Biochemie

Computational Alanine Scanning Mutagenesis of Protein-Peptide Interface

Computational Alanine Scanning Mutagenesis of Protein-Peptide Interface

Predicting Amino Acid Preferences of Protein-Protein Binding Interfaces

DOI:

10.3791/201497-v

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02:23 min

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January 26, 2024

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Héctor Cruz², Alejandro Llanes³, Patricia L. Fernández³

¹Facultad de Ciencias y Tecnología,Universidad Tecnológica de Panamá (UTP), ²Centro de Biología Molecular y Celular de Enfermedades,Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT AIP), ³Sistema Nacional de Investigación de Panamá (SNI)

Tags

Computational Prediction Amino Acid Preferences Peptide-binding Domains Protein-protein Interactions Multispecific Binding Interferon Regulatory Factor 5 (IRF5)Position-weight Matrix (PWM)Flexible-backbone Peptide Docking Rosetta Molecular Modeling

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