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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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Kapitel
- 00:00Titel
- 01:03Introduction
- 01:32Preparing the Protein
- 03:24Preparing the RNA Pool
- 07:58RNA-Protein Incubation and Filter Binding
- 13:24Representative Results of SELEX for Amyloid -Protein
- 14:41Conclusion
Aptamers are short ribo-/deoxyribo-oligonucleotides selected by in-vitro evolution methods based on affinity for a specific target. Aptamers are molecular recognition tools with versatile therapeutic, diagnostic, and research applications. We demonstrate methods for selection of aptamers for amyloid β-protein, the causative agent of Alzheimer's disease.
Tags
AptamersAmyloid β-proteinAlzheimer’s DiseaseNeurodegenerative DisorderPresymptomatic DiagnosisEarly DiagnosisEffective TherapiesAβ AssembliesSynaptic DysfunctionNeuron LossAD EtiologyAD PathogenesisMolecular Recognition ToolsAntibodiesAptamers AdvantagesSELEX (systematic Evolution Of Ligands By Exponential Enrichment)
