Personal protective equipment, or PPE, is specialized clothing or equipment used to minimize or prevent exposure to infectious agents. It helps to create a barrier between the wearer and infectious materials. Gloves help to reduce the risk of hand contamination and disease transmission. Gowns and aprons help to protect skin and clothing. Face masks cover the mucous membranes of the mouth and nose. Face shields and goggles protect the face and eyes. However, respirators offer ultimate protection from the inhalation and spread of airborne pathogens. Head and shoe covers protect the hair, scalp, and shoes from splashes of body fluids and airborne and chemical exposures. PPE should be donned before contact with the patient, specifically before entering the patient's room. It is crucial to carefully remove and dispose of the PPE before exiting the patient's room, except for respiratory protective devices, which must not be removed until completely outside the closed door to the patient's room. The wearer must also wash their hands immediately after doffing the PPE.