Mark Van de Casteele Diabetes Research Center Vrije Universiteit Brussel Biography Publications Institution JoVE Articles Mark Van de Casteele has not added a biography. If you are Mark Van de Casteele and would like to personalize this page please email our Author Liaison for assistance. Publications Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury Diabetes. May, 2015 | Pubmed ID: 26015547 Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration Stem Cells Translational Medicine. Jun, 2015 | Pubmed ID: 25848123 Macrophage Dynamics Are Regulated by Local Macrophage Proliferation and Monocyte Recruitment in Injured Pancreas European Journal of Immunology. May, 2015 | Pubmed ID: 25645754 Partial Duct Ligation: β-cell Proliferation and Beyond Diabetes. Aug, 2014 | Pubmed ID: 25060885 IL-6-dependent Proliferation of Alpha Cells in Mice with Partial Pancreatic-duct Ligation Diabetologia. Jul, 2014 | Pubmed ID: 24759958 Transient Cytokine Treatment Induces Acinar Cell Reprogramming and Regenerates Functional Beta Cell Mass in Diabetic Mice Nature Biotechnology. Jan, 2014 | Pubmed ID: 24240391 Short-term Overexpression of VEGF-A in Mouse Beta Cells Indirectly Stimulates Their Proliferation and Protects Against Diabetes Diabetologia. Jan, 2014 | Pubmed ID: 24121626 Mouse Beta Cell Proliferation is Inhibited by Thymidine Analogue Labelling Diabetologia. Dec, 2013 | Pubmed ID: 24026213 Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult β-cell Mass or Function Diabetes. Dec, 2013 | Pubmed ID: 23974922 Spatiotemporal Patterns of Multipotentiality in Ptf1a-expressing Cells During Pancreas Organogenesis and Injury-induced Facultative Restoration Development (Cambridge, England). Feb, 2013 | Pubmed ID: 23325761 Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-mediated Reprogramming PloS One. 2012 | Pubmed ID: 22606327 Interaction of Glibenclamide and Metformin at the Level of Translation in Pancreatic β Cells The Journal of Endocrinology. Feb, 2011 | Pubmed ID: 21084384 Derepression of Polycomb Targets During Pancreatic Organogenesis Allows Insulin-producing Beta-cells to Adopt a Neural Gene Activity Program Genome Research. Jun, 2010 | Pubmed ID: 20395405 Ectopic Expression of E2F1 Stimulates Beta-cell Proliferation and Function Diabetes. Jun, 2010 | Pubmed ID: 20299467 Akt Activation Protects Pancreatic Beta Cells from AMPK-mediated Death Through Stimulation of MTOR Biochemical Pharmacology. May, 2008 | Pubmed ID: 18377870 Beta Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas Cell. Jan, 2008 | Pubmed ID: 18243096 Specificity in Beta Cell Expression of L-3-hydroxyacyl-CoA Dehydrogenase, Short Chain, and Potential Role in Down-regulating Insulin Release The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17491019 Glucagon-like Peptide-1 Stimulates GABA Formation by Pancreatic Beta-cells at the Level of Glutamate Decarboxylase American Journal of Physiology. Endocrinology and Metabolism. Apr, 2007 | Pubmed ID: 17190904 Glycemic Control of Apoptosis in the Pancreatic Beta Cell: Danger of Extremes? Antioxidants & Redox Signaling. Mar, 2007 | Pubmed ID: 17184175 Increased Oxygen Radical Formation and Mitochondrial Dysfunction Mediate Beta Cell Apoptosis Under Conditions of AMP-activated Protein Kinase Stimulation Free Radical Biology & Medicine. Jan, 2007 | Pubmed ID: 17157194 IA1 is NGN3-dependent and Essential for Differentiation of the Endocrine Pancreas The EMBO Journal. Mar, 2006 | Pubmed ID: 16511571 Glucose Inhibits GABA Release by Pancreatic Beta-cells Through an Increase in GABA Shunt Activity American Journal of Physiology. Endocrinology and Metabolism. Mar, 2006 | Pubmed ID: 16249254 Metformin Reduces Adiponectin Protein Expression and Release in 3T3-L1 Adipocytes Involving Activation of AMP Activated Protein Kinase European Journal of Pharmacology. Aug, 2005 | Pubmed ID: 16039647 Adiponectin-mediated Stimulation of AMP-activated Protein Kinase (AMPK) in Pancreatic Beta Cells Life Sciences. Jul, 2005 | Pubmed ID: 15893773 Glucose Suppresses Superoxide Generation in Metabolically Responsive Pancreatic Beta Cells The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15774474 Metformin-induced Stimulation of AMP-activated Protein Kinase in Beta-cells Impairs Their Glucose Responsiveness and Can Lead to Apoptosis Biochemical Pharmacology. Aug, 2004 | Pubmed ID: 15242807 Dihydropteridine Reductase As an Alternative to Dihydrofolate Reductase for Synthesis of Tetrahydrofolate in Thermus Thermophilus Journal of Bacteriology. Jan, 2004 | Pubmed ID: 14702303 Prolonged Culture in Low Glucose Induces Apoptosis of Rat Pancreatic Beta-cells Through Induction of C-myc Biochemical and Biophysical Research Communications. Dec, 2003 | Pubmed ID: 14651961 Variations in IB1/JIP1 Expression Regulate Susceptibility of Beta-cells to Cytokine-induced Apoptosis Irrespective of C-Jun NH2-terminal Kinase Signaling Diabetes. Oct, 2003 | Pubmed ID: 14514632 Purification of Rat Pancreatic B-cells by Fluorescence-activated Cell Sorting Methods in Molecular Medicine. 2003 | Pubmed ID: 12619712 Recapitulation of Embryonic Neuroendocrine Differentiation in Adult Human Pancreatic Duct Cells Expressing Neurogenin 3 The Journal of Cell Biology. Oct, 2002 | Pubmed ID: 12403815 Sustained Activation of AMP-activated Protein Kinase Induces C-Jun N-terminal Kinase Activation and Apoptosis in Liver Cells FEBS Letters. Aug, 2002 | Pubmed ID: 12208500 Specific Expression of Bax-omega in Pancreatic Beta-cells is Down-regulated by Cytokines Before the Onset of Apoptosis Endocrinology. Jan, 2002 | Pubmed ID: 11751624 Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation Sofie De Groef1, Gunter Leuckx1, Naomi Van Gassen1, Willem Staels1, Ying Cai1, Yixing Yuchi1, Violette Coppens1, Nico De Leu1, Yves Heremans1, Luc Baeyens1, Mark Van de Casteele1, Harry Heimberg1 1Diabetes Research Center, Vrije Universiteit Brussel JoVE 52765 Medizin
Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation Sofie De Groef1, Gunter Leuckx1, Naomi Van Gassen1, Willem Staels1, Ying Cai1, Yixing Yuchi1, Violette Coppens1, Nico De Leu1, Yves Heremans1, Luc Baeyens1, Mark Van de Casteele1, Harry Heimberg1 1Diabetes Research Center, Vrije Universiteit Brussel JoVE 52765 Medizin