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Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System
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09:07 min
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February 10, 2023
DOI:
1Department of Neurosurgery,Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering,Johns Hopkins University, 3Krieger School of Arts and Sciences,Johns Hopkins University, 4Department of Electrical Engineering and Computer Science,Johns Hopkins University, 5Department of Radiology, Cancer Imaging Division,Johns Hopkins University School of Medicine, 6Department of Mechanical Engineering,Johns Hopkins University, 7Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University School of Medicine
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Here, we describe a protocol that details how to perform sonodynamic therapy in an in vivo mouse glioblastoma model using magnetic resonance-guided focused ultrasound.
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Sonodynamic TherapyGlioblastoma MultiformeFocused UltrasoundMR-guidedBrain TumorNon-invasivePreclinicalRodent ModelIncision-freeTumor-specificLow Intensity UltrasoundMR GuidanceCentral Nervous System DiseasesNon-ionizing RadiationMRI BedAnesthetized AnimalStereotactic Ear BarNose ConeBite BarMRI Compatible ScrewsPhantomMRI Cradle
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Mess, G., Anderson, T., Kapoor, S., Thombre, R., Liang, R., Derin, E., Kempski-Leadingham, K. M., Yadav, S. K., Tyler, B., Manbachi, A. Sonodynamic Therapy for the Treatment of Glioblastoma Multiforme in a Mouse Model Using a Portable Benchtop Focused Ultrasound System. J. Vis. Exp. (192), e65114, doi:10.3791/65114 (2023).
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