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A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia
JoVE 杂志
免疫与感染
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JoVE 杂志 免疫与感染
A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia

1,830 Views

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09:12 min

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February 03, 2023

DOI:

10.3791/65044-v

DOI:
10.3791/65044-v

•

09:12 min
February 03, 2023

•

21 Views
, , , ,
1School of Medicine,South China University of Technology, 2Provincial Key Laboratory of Research in Structure Birth Defect Disease and Department of Pediatric Surgery,Guangzhou Women and Children’s Medical Center

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We established a mouse model of chronic liver fibrosis, which provides a suitable animal model for the virus-induced liver fibrosis mechanistic study of biliary atresia (BA) and a platform for future BA treatments.

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Mouse ModelChronic Liver FibrosisBiliary AtresiaRhesus RotavirusAnti-Ly6G AntibodyIntraperitoneal InjectionLiver FunctionFluorescent DyeGallbladderExtrahepatic Bile Ducts

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Wang, X., Zhang, R., Lin, Z., Fu, M., Chen, Y. A Mouse Model of Chronic Liver Fibrosis for the Study of Biliary Atresia. J. Vis. Exp. (192), e65044, doi:10.3791/65044 (2023).

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