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Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
1Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience,University of Bristol, 2Eli Lilly and Company, 3Department of Computer Science,University of Bristol, 4Department of Aerospace Engineering,University of Bristol, 5Research Computing,University of Bristol
Chapters
- 00:04Introduction
- 01:29Assembly of the Recording and Stimulating Apparatus
- 03:27Software Setup and Identification and Phenotyping of Peripheral Neurons
- 05:43Latency and Electrical Threshold Tracking
- 08:00Results: Electrical Threshold Tracking of Single‐Neuron Action Potentials
- 09:43Conclusion
APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and Aδ-fiber nociceptors.
Tags
Open-sourceReal-timeClosed-loopElectrical Threshold TrackingTranslational Pain ResearchNociceptor SensitizationAutomated Electrical Threshold TrackingNociceptor ExcitabilityBiomarkerAP TrackElectrophysiologyOptogeneticsAcquisition BoardIO BoardIntan RHD Recording HeadstagePulse PalConstant Current StimulatorStepper Motor Control BoardCustom Mounting BracketBarrel Adapter
