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Development of a Uterosacral Ligament Suspension Rat Model
 

Development of a Uterosacral Ligament Suspension Rat Model

Article DOI: 10.3791/64311-v • 08:58 min • August 17th, 2022
August 17th, 2022 •
1, 2, 3, 1,3, 4
1Department of Chemical Engineering, University of Virginia, 2Electrophysiology Division, Abbott, 3Department of Biomedical Engineering, University of Virginia, 4Department of Obstetrics and Gynecology, Division of Pelvic Medicine and Reconstructive Surgery, University of Virginia

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Automatic Translation

Pelvic organ prolapse affects millions of women worldwide and yet some common surgical interventions have failure rates as high as 40%. The lack of standard animal models to investigate this condition impedes progress. We propose the following protocol as a model for uterosacral ligament suspension and in vivo tensile testing.

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Uterosacral Ligament Suspension Rat Model Preclinical Outcomes Surgery Modifications Anatomy Cellularity Histological Architecture Composition Cost Benefits Feasibility Augmentation Outcomes Tensile Testing Method Pelvic Floor Animal Models General Surgery Setup Prolapse Surgeries Sacrocolpopexy Surgical Gown Sterile Field Incision Linea Alba
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