Journal
/
免疫与感染
/
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
JoVE 杂志
免疫与感染
需要订阅 JoVE 才能查看此.  登录或开始免费试用。
JoVE 杂志 免疫与感染
Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

DOI:
10.3791/63696-v

•

06:07 min

•

October 06, 2022

•

, , , , , ,
1Division of Hematology and Oncology, David Geffen School of Medicine,University of California, Los Angeles

Chapters

  • 00:05Introduction
  • 01:07Preparation and Administration of ART Drugs to HIV-1 Infected Mice
  • 03:59Results: A Method for Oral Administration of cART for HIV-1 Infected Humanized Mice
  • 05:38Conclusion

Summary

自动翻译

自动翻译

This protocol describes a novel method to deliver oral combinational antiretroviral drugs that successfully suppress HIV-1 RNA replication in humanized mice.

Tags

Oral Antiretroviral TreatmentHIV-1Humanized MiceCARTFTCTDFRALELVDMSOTrimethoprim SulfamethoxazoleDrug DeliveryPreclinical StudiesHIV Cure

Article

Embed

添加到播放列表

Usage Statistics

Related Videos

Genotypic Inference of HIV-1 Tropism Using Population-based Sequencing of V3

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

In vitro Uncoating of HIV-1 Cores

Imaging of HIV-1 Envelope-induced Virological Synapse and Signaling on Synthetic Lipid Bilayers

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals

Phagosome Migration and Velocity Measured in Live Primary Human Macrophages Infected with HIV-1

Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes

Read Article