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Retrograde Parotid Gland Infusion through Stensen’s Duct in a Non-Human Primate for Vectored Gene Delivery
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03:50 min
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August 12, 2021
DOI:
1Department of Medicine, Division of Infectious Diseases and Global Medicine,University of Florida, 2Department of Otolaryngology,George Washington University School of Medicine, 3Department of Medicine, Section on Infectious Diseases,Wake Forest Baptist Medical Center, 4Department of Pathology,Wake Forest School of Medicine, 5Department of Medicine, Section of Infectious Diseases,Hefner Veterans Affairs Medical Center
Summary
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Salivary glands have been proposed as a tissue target site for gene therapy, especially in the area of vaccination by gene transfer. We demonstrate gene delivery in a non-human primate model utilizing retrograde parotid infusion.
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Cite this Article
El Helou, G., Goodman, J. F., Blevins, M., Caudell, D. L., Ponzio, T. A., Sanders, J. W. Retrograde Parotid Gland Infusion through Stensen's Duct in a Non-Human Primate for Vectored Gene Delivery. J. Vis. Exp. (174), e62645, doi:10.3791/62645 (2021).
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