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神经科学
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
JoVE 杂志
神经科学
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JoVE 杂志 神经科学
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

10,987 Views

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09:41 min

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July 19, 2019

DOI:

10.3791/59511-v

DOI:
10.3791/59511-v

•

09:41 min
July 19, 2019

•

4 Views
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1Department of Neurosciences, Lerner Research Institute,Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute,Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute,Cleveland Clinic

Summary

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Multiple sclerosis is an inflammatory demyelinating disease with no cure. Analysis of brain tissue provides important clues to understanding the pathogenesis of the disease. Here we discuss the methodology and downstream analysis of MS brain tissue collected through a unique rapid autopsy program in operation at the Cleveland Clinic.

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Dutta, R., Mahajan, K. R., Nakamura, K., Ontaneda, D., Chen, J., Volsko, C., Dudman, J., Christie, E., Dunham, J., Fox, R. J., Trapp, B. D. Comprehensive Autopsy Program for Individuals with Multiple Sclerosis. J. Vis. Exp. (149), e59511, doi:10.3791/59511 (2019).

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