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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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JoVE 杂志 免疫与感染
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

DOI:
10.3791/59132-v

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04:23 min

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April 28, 2019

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, , , , , , ,
1Graduate Institute of Medical Sciences, College of Medicine,Taipei Medical University, 2Department of Microbiology and Immunology, School of Medicine, College of Medicine,Taipei Medical University, 3Center of Infectious Disease and Signaling Research,National Cheng Kung University

Chapters

  • 00:04Title
  • 00:44Infection Procedure and Disease Scoring
  • 02:16Results: Representative Establishment of Mouse Dengue Virus-induced Acute Viral Encephalitis-like Disease
  • 03:06Conclusion

Summary

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Here, we present a protocol for creating an immunocompetent ICR (Institute of Cancer Research) murine model of central nervous system infection to display the development of neuropathy. Monitoring acute viral encephalitic disorders by identical disease scores could be performed for showing dengue virus-induced neuropathy in vivo.

Tags

Murine ModelDengue VirusAcute Viral EncephalitisNeuropathogenesisVirus InfectionVirus InoculationDisease ProgressionBody Weight ChangesSurvival Rates

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