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The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
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医学
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JoVE 杂志 医学
The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats

DOI:
10.3791/59050-v

•

07:29 min

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March 08, 2019

•

, , , , , , ,
1Cardiovascular Research Center, Department of Cardiology,Icahn School of Medicine at Mount Sinai

Chapters

  • 00:04Title
  • 01:06Rat Intubation and Sterile Environment Preparation
  • 02:23Left Pneumonectomy
  • 04:34Ribs and Intercostal Muscle Closure
  • 05:37Results: Representative Pulmonary Hypertension in Rats
  • 06:40Conclusion

Summary

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自动翻译

The rodent left pneumonectomy is a valuable technique in pulmonary hypertension research. Here, we present a protocol to describe the rat pneumonectomy procedure and postoperative care to ensure minimal morbidity and mortality.

Tags

Keywords: Pulmonary Arterial HypertensionPneumonectomyMonocrotalineSugenRat ModelEndothelial DamageRegenerative MedicineCongenital Heart DefectsPost-pneumonectomyAnesthesiaIntubationThoracotomyLung ResectionSurgical Technique

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