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化学抑制剂库筛选 t 细胞受体信号的中介识别
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JoVE 杂志 免疫与感染
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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化学抑制剂库筛选 t 细胞受体信号的中介识别

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08:49 min

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January 22, 2019

DOI:

10.3791/58946-v

DOI:
10.3791/58946-v

•

08:49 min
January 22, 2019

•

3 Views
, , , ,
1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine,National University of Singapore, 2Singapore Immunology Network,A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research,Katholieke Universiteit (KU) Leuven

Summary

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本文采用基于流式细胞仪的检测方法筛选化学抑制剂文库, 用于鉴定影响 t 细胞受体信号转导的抑制剂及其靶点。此处描述的方法也可以扩展为高通量筛选。

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Cite this Article

Chen, E. W., Ke, C. Y., Brzostek, J., Gascoigne, N. R. J., Rybakin, V. Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries. J. Vis. Exp. (143), e58946, doi:10.3791/58946 (2019).

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