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Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
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JoVE 杂志 工程学
Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles

DOI:
10.3791/58725-v

•

05:07 min

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March 18, 2019

•

, , , ,
1Department of Environmental Engineering,Inha University, 2HCTM Co. Ltd

Chapters

  • 00:04Title
  • 00:32Single-Concentration Exposure Chamber Testing with 0.1 wt% NaCl
  • 01:50Multiconcentration Exposure Chamber Testing with 0.1 wt% NaCl
  • 03:38Results: Flow and Particle Concentration Uniformity
  • 04:32Conclusion

Summary

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A nose-only inhalation toxicity chamber capable of testing inhalation toxicity at four different exposure concentrations was designed and validated for flow field uniformity and cross-contamination between the exposure ports for each concentration. Here, we present a protocol to confirm that the designed chamber is effective for inhalation toxicity testing.

Tags

Keywords: Nose-only InhalationToxicity Test ChamberMulti-concentration ExposureNano-sized ParticlesOECD GuidelinesFlow VelocityParticle Size DistributionSodium Chloride AerosolAir FlowPressure DifferentialHumidity Control

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