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Uso de transplante de células-tronco hematopoiéticas para avaliar a origem da síndrome mielodisplásica
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发育生物学
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JoVE 杂志 发育生物学
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Uso de transplante de células-tronco hematopoiéticas para avaliar a origem da síndrome mielodisplásica

9,681 Views

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06:39 min

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October 03, 2018

DOI:

10.3791/58140-v

DOI:
10.3791/58140-v

•

06:39 min
October 03, 2018

•

7 Views
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1Genetics Branch,Center for Cancer Research, National Cancer Institute, National Institutes of Health, 2LGI Flow Cytometry Core Facility,Center for Cancer Research, National Cancer Institute, National Institutes of Health

Summary

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Nós descrevemos o uso do transplante de células-tronco hematopoéticas (TCTH) para avaliar o potencial maligno das células hematopoiéticas geneticamente modificados. TCTH é útil para avaliar várias células hematopoiéticas malignas na vivo , bem como gerar uma grande coorte de ratos com Síndromes Mielodisplásicas (MDS) ou leucemia para avaliar novas terapias.

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Chung, Y. J., Khawaja, G., Wolcott, K. M., Aplan, P. D. Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome. J. Vis. Exp. (140), e58140, doi:10.3791/58140 (2018).

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