Identification of genetic variants contributing to complex human disease allows us to identify novel mechanisms. Here, we demonstrate a multiplex genotyping approach to candidate genes or gene pathway analysis that maximizes the coverage at low cost and is amenable to cohort-based studies.
Ashley, S. E., Meyer, B. A., Ellis, J. A., Martino, D. J. Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry. J. Vis. Exp. (136), e57601, doi:10.3791/57601 (2018).