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Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
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神经科学
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JoVE 杂志 神经科学
Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

7,853 Views

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06:04 min

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September 02, 2020

DOI:

10.3791/57570-v

DOI:
10.3791/57570-v

•

06:04 min
September 02, 2020

•

7 Views
, ,
1Laboratory of Clinical Pharmacy and Pharmacology,Musashino University, 2Research Institute of Pharmaceutical Sciences,Musashino University

Summary

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The transient receptor potential vanilloid type 1 (TRPV1) in the supraspinal region has been suggested to play some roles in the brain function. Described here is a protocol for intracerebroventricular injection of resiniferatoxin for supraspinal TRPV1 desensitization in mice. Procedures for some pain tests are also presented.

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Cite this Article

Fukushima, A., Fujii, M., Ono, H. Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice. J. Vis. Exp. (163), e57570, doi:10.3791/57570 (2020).

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