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Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model
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JoVE 杂志 生物学
Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

DOI:
10.3791/57340-v

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08:46 min

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June 27, 2018

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, , , , ,
1State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences,Nankai University

Chapters

  • 00:04Title
  • 00:59Fabrication of Electrospun PCL Grafts
  • 02:54Electrospun PCL Graft Characterization
  • 03:57Rat Abdominal Aorta Implantation Model
  • 07:11Results: Regenerated Tissue is Supported by PCL Grafts
  • 08:16Conclusion

Summary

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Here, we present a modified electrospinning method to fabricate PCL vascular grafts with thick fibers and large pores, and describe a protocol to evaluate the in vivo performance in a rat model of abdominal aorta replacement.

Tags

Keywords: Electrospun Vascular GraftPolycaprolactoneFiber DiameterPore SizeTensile TestingSEM ImagingRat Abdominal Aorta ImplantationVascular Regeneration

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