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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
JoVE 杂志
医学
This content is Free Access.
JoVE 杂志 医学
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

DOI:
10.3791/56596-v

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09:15 min

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November 10, 2017

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, , , , , , ,
1Plaxgen Inc, 2Millipore Sigma, 3Cytometry Laboratories,Purdue University, 4San Francisco General Hospital, 2M16 Clinical Chemistry,University of California, San Francisco, 5Molecular Medicine Research Institute

Chapters

  • 00:05Title
  • 01:22Plaque Array Assay for Examining In Vitro Cholesterol Particles Formation
  • 02:45Capturing Images of Cholestrerol Particles Using Imaging Flow Cytometry
  • 04:04Analyzing the Effect of Drugs on Cholestrerol Particle Formation in Serum Samples
  • 06:21Results: Evaluating the Effects of Lipid-lowering Drugs on Modulating Morphology of Cholesterol Particles
  • 08:25Conclusion

Summary

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The objective of this study was to evaluate in vitro lipid-lowering drug effects in modulating the morphology of cholesterol particles. Comparison of lipid-lowering drugs revealed variations in their effect in modulating the morphological features of cholesterol particles.

Tags

Keywords: Cholesterol ParticlesLipid-lowering DrugsPlaque ArrayMorphological FeaturesIn Vitro ImagingBiomarkersAtherosclerosisChemistry AnalyzerImaging Flow CytometryData Analysis

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