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Pentylenetetrazole-induceret Kindling musemodel
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JoVE 杂志 神经科学
Pentylenetetrazole-Induced Kindling Mouse Model

Pentylenetetrazole-induceret Kindling musemodel

DOI:
10.3791/56573-v

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07:06 min

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June 12, 2018

•

,
1Synaptic Plasticity Project,Tokyo Metropolitan Institute of Medical Science

Chapters

  • 00:04Title
  • 00:38Injection of PTZ
  • 01:20Three Chamber Test
  • 04:18Contextual Fear Discrimination
  • 05:29Results: Repetitive Injection of PTZ Induces an Increase in Seizure Severity
  • 06:26Conclusion

Summary

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自动翻译

Denne protokol beskriver en metode til kemisk kindling med pentylenetetrazole og giver en musemodel af epilepsi. Denne protokol kan også bruges til at undersøge sårbarhed over for beslaglæggelse induktion og patogenese efter epileptiske anfald hos mus.

Tags

Pentylenetetrazole-Induced KindlingMouse ModelEpilepsySeizureHistological ChangesNeuropsychiatric DisordersPTZSodium ChlorideIntraperitoneal Injection129 SV MiceThree-Chamber ApparatusHabituationSocial InteractionBehavioral Parameters

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