需要订阅 JoVE 才能查看此. 登录或开始免费试用。
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
1Center for Addiction Research,University of Texas Medical Branch, 2Institute for Translational Sciences,University of Texas Medical Branch, 3Mitchell Center for Neurodegenerative Diseases,University of Texas Medical Branch, 4Department of Neurology,University of Texas Medical Branch, 5Department of Pathology,University of Texas Medical Branch, 6Department of Pharmacology and Toxicology,University of Texas Medical Branch
Chapters
- 00:04Title
- 01:01Preparing Rats for the Training
- 02:28Self-Administration Training
- 04:59Forced Abstinence and Cue Reactivity Testing
- 06:08Results: Cue Reactivity Test Data
- 07:08Conclusion
Cue reactivity is conceptualized as sensitivity to cues linked with drug-taking experiences that contribute to craving and relapse in abstinent humans. Cue reactivity is modeled in rats by measuring attentional orientation toward drug-associated cues that results in appetitive approach behavior in a cue reactivity test following self-administration and forced abstinence.
