00:51Preparation of Samples and NMR Instrument for 19F TD-NMR Measurement
01:56Measurement of the T1 or Longitudinal Relaxation Time for Standard Pure API Samples
03:23Measuring Calibration Samples with Pure API
04:29Measuring Drug Product Samples as Tablets
04:59Generation of Calibration Curves with Pure API Samples and Adding the Data from Drug Product Samples as Tablets in the Calibration Curve
06:59Calculation of the Fluorinated API Drug Weight in the Formulated Drug Product Using the Calibration Curves
07:33Results: Evaluation of the Average Drug Content of Cinacalcet in Tablet Dosage Forms by Low-field Fluorine-19 Time-domain Nuclear Magnetic Resonance
Una técnica sencilla y no destructivo que mide el contenido promedio de drogas sustancias en medicamentos formulados, que contienen flúor utilizando bajo campo flúor-19 (19F) dominio de tiempo (TD) resonancia magnética (RMN) se presenta aquí. La técnica puede ser aplicada al desarrollo y fabricación de medicamentos en la industria farmacéutica.