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Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
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JoVE 杂志 化学
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

DOI:
10.3791/55188-v

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10:54 min

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February 04, 2017

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, , , ,
1Department of Chemistry and Chemical Biology,McMaster University

Chapters

  • 00:05Title
  • 01:08Radiolabeling of Tetrazines via Chelation to 99mTc
  • 04:30Pre-targeted Biodistribution Studies
  • 08:21Results: Bio-distribution of 99mTc-labeled Tetrazine Complexes
  • 09:56Conclusion

Summary

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Here, we describe a protocol for radiolabeling and in vivo testing of tridentate 99mTc(I) chelate-tetrazine derivatives for pre-targeting and bioorthogonal chemistry.

Tags

99mTc-labeled Tridentate ChelatesPre-targetingBioorthogonal ChemistryTetrazinesTechnetium-99mRadiolabelingMicrowave SynthesisTargeting VectorsRadiopharmaceuticalsDiagnostic ImagingRadiotherapy

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