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Chapters
- 00:05Title
- 01:14Infrarenal Aortic Clamping
- 03:59Closure of Laparotomy and Postoperative Assessment
- 04:58Aortic Dissection and Staining
- 05:40Results: Efficiency of Endothelial Denudation and Reproducibility and Denudation Injury
- 07:28Conclusion
Understanding the cellular and molecular mechanisms of re-endothelialization following arterial denudation injury is of paramount importance in preventing thrombosis and restenosis of arteries. Here we describe a protocol for reproducible arterial denudation injury of the infrarenal abdominal aorta. The procedure was developed to investigate the underlying mechanisms that regulate endothelial regeneration using mouse models.
Tags
Keywords:
Arterial DenudationAortic ClampingMurine ModelVascular BiologyEndothelial RegenerationEndothelial Cell ProgenitorsVascular InjuryRe-endothelializationThrombotic EventsStent DeploymentCoronary Artery DiseasePeripheral Vascular DiseaseSurgical ProcedureAnesthesiaAbdominal IncisionIntestine RetractionRetroperitoneal DissectionAortic Exposure
