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Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice
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Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

Whisker-signaled Eyeblink Classical Conditioning in Head-fixed Mice

DOI:
10.3791/53310-v

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10:14 min

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March 30, 2016

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, ,
1Department of Physiology,Northwestern University

Chapters

  • 00:05Title
  • 01:00Preparing the Headpiece
  • 02:50Surgery
  • 07:03Habituating the Mouse to the Cylinder
  • 08:23Results: Conditioned Response to Paired and Unpaired Stimulus
  • 09:24Conclusion

Summary

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自动翻译

The preparation presented here for whisker-signaled eyeblink conditioning in head-fixed mice precisely stimulates specific whiskers while allowing mice to ambulate on a cylindrical treadmill. A whisker stimulation conditioned stimulus (CS) paired with a periorbital shock unconditioned stimulus (US) results in reliable associative learning on this apparatus.

Tags

Keywords: Whisker-signaledEyeblinkClassical ConditioningHead-fixedMiceGenetic ManipulationCalcium ImagingElectrophysiologyMemoryAgingAlzheimer’s DiseaseHeadpiece3D PrintedElectrical StimulationEMGAnesthesiaAnalgesiaStereotaxic FrameScalp Disinfection

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