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인공 와우 세포 변성을 유도하기위한 신속하고 신뢰할 수있는 기술 : Ototoxic 에이전트 배달을 위해 마우스 라운드 창 접근
JoVE 杂志
医学
This content is Free Access.
JoVE 杂志 医学
The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
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인공 와우 세포 변성을 유도하기위한 신속하고 신뢰할 수있는 기술 : Ototoxic 에이전트 배달을 위해 마우스 라운드 창 접근

16,551 Views

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12:21 min

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November 26, 2015

DOI:

10.3791/53131-v

DOI:
10.3791/53131-v

•

12:21 min
November 26, 2015

•

11 Views
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1Department of Otolaryngology Head and Neck Surgery,Medical University of South Carolina, 2Department of Pathology and Laboratory Sciences,Medical University of South Carolina, 3Intuitive Surgical, Inc

Summary

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Various methods exist for introducing ototoxic agents to the cochleae of animal models. Presented is a surgical protocol for delivery of ototoxic agents to the round window niche. The procedure is reliable, creates targeted intra-cochlear lesions, and avoids mechanical damage to the microarchitecture. Examination of cochlear self-repair/regeneration is possible.

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Cochlear Cell DegenerationOtotoxic Agent DeliveryRound Window NicheCochlear InjuryAuditory PathophysiologyCochlear Cell RegenerationAnimal ModelHearing Loss

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Cite this Article

Stevens, S. M., Brown, L. N., Ezell, P. C., Lang, H. The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration. J. Vis. Exp. (105), e53131, doi:10.3791/53131 (2015).

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