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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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化学
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JoVE 杂志 化学
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

DOI:
10.3791/53047-v

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07:32 min

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August 28, 2015

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, , , ,
1School of Pharmacy,Pacific University, 2Department of Pharmaceutical Sciences, College of Pharmacy,Oregon State University

Chapters

  • 00:05Title
  • 01:42Preparation of Individual and Multi-drug Loaded Micelles by Solvent Casting Method
  • 02:56Assessment of Drug Loading and Stability in Micelles Using Reverse-phase High Performance Liquid Chromatography
  • 03:52Assessment of Micelle Particle Size by Dynamic Light Scattering
  • 04:29Assessment of In Vitro Drug Release from Individual Micelles and Dual Drug Micelles
  • 05:21Results: Preparation and Characterization of Poorly Water Soluble Drugs in Micelles
  • 06:29Conclusion

Summary

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The goal of this protocol is to describe the preparation and characterization of physically entrapped, poorly water soluble drugs in micellar drug delivery systems composed of amphiphilic block copolymers.

Tags

Keywords: Polymeric MicellesPEG-b-PLADocetaxelEverolimusSolvent CastingDrug LoadingDrug StabilityDrug ReleaseDynamic Light ScatteringCharacterization

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