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Journal / Medicine / Three-Dimensional (3D) Tumor Spheroid Invasion…
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Three-Dimensional (3D) Tumor Spheroid Invasion Assay
 

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Article DOI: 10.3791/52686-v • 12:19 min • May 1st, 2015
May 1st, 2015 •
1,2, 2, 2
1Division of Molecular Pathology, The Institute of Cancer Research, 2Division of Cancer Therapeutics, The Institute of Cancer Research

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Invasion of surrounding normal tissues is a defining characteristic of malignant tumors. We provide here a simple, semi-automated micro-plate assay of invasion into a natural 3D biomatrix that has been exemplified with a number of models of advanced human cancers.

Tags

3D Tumor Spheroid Invasion Assay Malignant Tumors Benign Tumors Brain Tumors Glioblastoma Multiforme Squamous Cell Carcinoma Of The Head And Neck SCCHN Invasion Of Surrounding Tissues Morbidity Life-threatening Distant Metastases Aggressive Phenotype Novel Therapies Standard Anti-proliferative Agents Robust Assays Reproducible Assays Detailed Analysis Of Invasion Drug Screening Micro-plate Method Self-assembling 3D Tumor Spheroids Human Glioblastoma Cell Line Resistance Against EGFR Inhibitors Matrix-invasive Potential Imaging Cytometer Digital Image Analysis
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