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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse
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神经科学
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JoVE 杂志 神经科学
3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

13,743 Views

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15:26 min

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May 19, 2015

DOI:

10.3791/52328-v

DOI:
10.3791/52328-v

•

15:26 min
May 19, 2015

•

4 Views
, , , , , , ,
1Department of Physiology and Neurobiology,University of Connecticut, 2Department of Anatomic Pathology and Laboratory Medicine,University of Connecticut Health Center

Summary

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Using MRI scans (human), 3D imaging software, and immunohistological analysis, we document changes to the brain’s lateral ventricles. Longitudinal 3D mapping of lateral ventricle volume changes and characterization of periventricular cellular changes that occur in the human brain due to aging or disease are then modeled in mice.

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3D ModelingLateral VentriclesEpendymal CellsVentriculomegalyCerebral Spinal FluidBrain AgingImmunohistochemistryMRIMouse Models

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Cite this Article

Acabchuk, R. L., Sun, Y., Wolferz, Jr., R., Eastman, M. B., Lennington, J. B., Shook, B. A., Wu, Q., Conover, J. C. 3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse. J. Vis. Exp. (99), e52328, doi:10.3791/52328 (2015).

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