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Chapters
- 00:05Title
- 01:16Coverslip Preparation
- 02:37Globoid Cell Induction in Mixed Glial Cultures
- 04:30Analysis and Characterization of Globoid Cells in Primary Culture
- 06:12Results: Representative Microglial Cells After Psychosine and Latex Bead Phagocytosis
- 07:15Conclusion
Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.
