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Coherent anti-Stokes Raman scattering (CARS) Microscopie Visualiseert Farmaceutische Tabletten tijdens het oplossen
JoVE 杂志
工程学
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JoVE 杂志 工程学
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Coherent anti-Stokes Raman scattering (CARS) Microscopie Visualiseert Farmaceutische Tabletten tijdens het oplossen

17,740 Views

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09:59 min

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July 04, 2014

DOI:

10.3791/51847-v

DOI:
10.3791/51847-v

•

09:59 min
July 04, 2014

•

3 Views
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1Optical Sciences Group, MESA+ Institute,University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics,Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy,University of Helsinki

Summary

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Coherente anti-Stokes Raman scattering (CARS) microscopie gecombineerd met een intrinsieke doorstroom ontbinding opstart om in situ en real-time visualisatie van het oppervlak van farmaceutische tabletten ondergaan oplossen. Met behulp van deze custom-built setup, is het mogelijk om auto's te correleren met drugs oplosprofielen opgenomen met inline UV-absorptie spectroscopie.

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Cite this Article

Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. J., Offerhaus, H. L. Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution. J. Vis. Exp. (89), e51847, doi:10.3791/51847 (2014).

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