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Coerenti anti-Stokes Raman Scattering (CARS) Microscopia visualizza farmaceutici compresse durante la dissoluzione
JoVE 杂志
工程学
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JoVE 杂志 工程学
Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
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Coerenti anti-Stokes Raman Scattering (CARS) Microscopia visualizza farmaceutici compresse durante la dissoluzione

17,740 Views

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09:59 min

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July 04, 2014

DOI:

10.3791/51847-v

DOI:
10.3791/51847-v

•

09:59 min
July 04, 2014

•

3 Views
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1Optical Sciences Group, MESA+ Institute,University of Twente, 2Institute of Pharmaceutics and Biopharmaceutics,Heinrich-Heine University, 3Division of Pharmaceutical Technology, Faculty of Pharmacy,University of Helsinki

Summary

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Anti-Stokes scattering Raman (CARS) microscopia coerente è combinato con un setup dissoluzione flusso continuo intrinseca per consentire in situ e visualizzazione in tempo reale della superficie di compresse farmaceutiche sottoposti a dissoluzione. Utilizzando questa configurazione su misura, è possibile correlare AUTO video con i profili di dissoluzione di droga registrati utilizzando la spettroscopia di assorbimento UV inline.

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Cite this Article

Fussell, A. L., Kleinebudde, P., Herek, J., Strachan, C. J., Offerhaus, H. L. Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution. J. Vis. Exp. (89), e51847, doi:10.3791/51847 (2014).

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